AQA Syllabus focus:
'The physiology of stress, including the role of cortisol.'
Cortisol is central to the body’s slower stress response. Understanding what it does, why it is useful, and how prolonged exposure can become damaging is essential for explaining the physiology of stress.
Cortisol is a glucocorticoid hormone released by the adrenal cortex during stress that helps mobilize energy and support a longer-lasting physiological response.
Cortisol in the stress response
When a person perceives a stressor, the body does not only produce a fast, immediate reaction.

This diagram summarizes the hypothalamic–pituitary–adrenal (HPA) axis pathway that drives cortisol release during stress. It shows the sequence CRH (hypothalamus) → ACTH (pituitary) → cortisol (adrenal cortex), helping you link brain control to endocrine output. Use it to remember that cortisol supports a slower, longer-lasting stage of the stress response. Source
It also produces a slower hormonal response designed to keep the body functioning if the stress continues. Cortisol is the main hormone involved in this longer-lasting stage.
Cortisol is often described as a stress hormone, but this can be misleading if it suggests that cortisol is always harmful. In fact, cortisol has an important adaptive function. It helps the body cope with demand by making sure enough energy is available and by shifting bodily resources toward immediate survival.
A useful way to think about cortisol is that it supports the body when stress is not over in a few seconds. Adrenaline acts quickly and prepares the body for immediate action, whereas cortisol acts more slowly and its effects last longer. This makes cortisol especially important in situations of ongoing pressure, uncertainty, or challenge.
Main roles of cortisol
Mobilizing energy
One of the most important roles of cortisol is to increase the availability of energy.
Under stress, the body needs fuel for the brain and muscles. Cortisol helps by:
increasing blood glucose
promoting the release of stored energy
ensuring that the body can continue responding if the stressor lasts
This is useful because stress response requires metabolic resources. A person who is under threat, pressure, or high demand needs a reliable supply of energy, and cortisol helps provide it.
Prioritizing immediate survival
Cortisol also helps the body prioritize short-term survival over long-term maintenance. During stress, not every bodily process is equally urgent. Cortisol helps shift resources away from processes that are less necessary in the moment.
This means that cortisol can reduce activity in functions such as:
digestion
growth
reproductive processes
some aspects of immune functioning
This redistribution of resources is helpful in the short term because it allows the body to focus on coping with the stressor. In effect, cortisol tells the body to invest in immediate action rather than routine maintenance.
Supporting a prolonged response
Cortisol is especially important because it helps the body maintain alertness and readiness over time. If stress continues, a very brief burst of physiological arousal would not be enough. Cortisol helps sustain the response so the individual can continue to manage the challenge.
This longer-lasting action is why cortisol is associated with chronic stress as well as acute stress.
It is not just involved in the start of the response; it helps keep the body prepared while the stressor remains.
Regulation of cortisol
In a healthy stress response, cortisol does not stay elevated forever. Once enough cortisol is circulating, it contributes to negative feedback, meaning that rising hormone levels help reduce further release. This allows the body to return toward its normal resting state when the stressor has passed.
This regulation is important because the benefits of cortisol depend on duration. Short-term elevation can be useful and protective. Prolonged elevation is much more likely to become harmful.
A balanced stress response therefore involves two stages:
cortisol rises when needed
cortisol falls again when the demand is over
If this reduction does not happen effectively, the person may remain in a state of physiological strain.
Why cortisol is useful in the short term
In the short term, cortisol plays a valuable role in helping the body cope efficiently with stress. It:
provides a steady supply of energy
helps maintain focus on the stressor
supports continued physiological readiness
allows the body to deal with challenge over a longer period than adrenaline alone could manage
Without cortisol, the body would be less able to sustain its response to ongoing stress. For this reason, cortisol should be seen as part of a normal and necessary survival system.
Why prolonged cortisol can be harmful
The problem of chronic elevation
The main issue is not cortisol itself, but too much cortisol for too long. If a person experiences repeated or continuous stress, cortisol levels may stay high over an extended period. Over time, this can place strain on the body and reduce efficient functioning.
Prolonged cortisol release may:
keep blood glucose elevated for too long
interfere with sleep and recovery
reduce the efficiency of the immune response
contribute to problems with memory and concentration
increase general wear and tear on the body
These effects help explain why long-term stress is associated with poorer health and functioning. The same hormone that is useful during short-term challenge can become damaging if exposure is too frequent or too prolonged.
Cortisol and the brain
Cortisol is also important because it affects brain functioning. In short bursts, this may help a person stay alert. However, when cortisol remains high for long periods, it can disrupt cognitive performance, especially attention and memory. This helps explain why chronically stressed people may feel mentally exhausted or less able to think clearly.
Key idea for this subtopic
For AQA Psychology, the most important point is that cortisol has a dual role:
it is adaptive in the short term because it helps the body respond effectively to stress
it can become maladaptive when stress is prolonged, because long-term exposure contributes to physiological and psychological strain
Practice Questions
Identify two roles of cortisol in the stress response. (2 marks)
1 mark for identifying that cortisol increases energy availability / raises blood glucose.
1 mark for identifying that cortisol supports a longer-lasting stress response.
1 mark for identifying that cortisol suppresses less urgent bodily processes during stress.
Credit any two accurate roles, maximum 2 marks.
Explain the role of cortisol in the stress response. Refer to both short-term and prolonged release. (6 marks)
Award 1 mark for each relevant point, up to 6 marks.
Cortisol is a hormone released during stress.
It is involved in the slower, longer-lasting stress response.
It helps mobilize energy / increases blood glucose.
It redirects resources away from non-essential functions such as digestion or growth.
In the short term, this is adaptive because it helps the body cope with ongoing stress.
If cortisol remains elevated for too long, it can become harmful.
Prolonged cortisol release may reduce immune efficiency.
Prolonged cortisol release may impair memory, concentration, sleep, or recovery.
Full marks require clear reference to both helpful short-term effects and harmful long-term effects.
FAQ
Cortisol follows a daily circadian rhythm, so it naturally rises before waking and is usually highest shortly after a person gets up. This is sometimes called the cortisol awakening response.
This morning increase is normal and helps promote alertness, energy availability, and readiness for the day. It is not, by itself, a sign that someone is stressed.
Common methods include:
saliva samples, which are easy and non-invasive
blood samples, which give direct hormone levels
hair samples, which can show longer-term cortisol exposure
Saliva is especially useful in stress research because samples can be taken repeatedly across the day. Hair cortisol is often used when researchers want to estimate chronic exposure over weeks or months.
Yes, intense exercise can temporarily raise cortisol because exercise places demand on the body. This is usually a normal, short-term response.
In most cases, this is not harmful. If recovery is adequate, the temporary increase in cortisol is part of adaptation. Problems are more likely when exercise is excessive, rest is poor, or physical stress becomes chronic.
Not everyone shows the same hormonal pattern. A blunted cortisol response can happen in some people who have experienced long-term stress, burnout, trauma, or repeated exposure to stressors.
This may reflect changes in how the body regulates stress hormones over time. A weaker response does not always mean the person is coping well; sometimes it suggests that the stress system has become dysregulated.
Several factors can change cortisol levels, including:
time of day
sleep loss
caffeine or nicotine
illness
medication, especially steroid-based drugs
hormonal contraception
Because of this, researchers try to control testing conditions carefully. Otherwise, changes in cortisol may reflect these outside influences rather than the stressor being studied.
